According to a study of 1,500 adults, the therapy most likely to maintain smoking cessation for 6 months after the quit date was a nicotine patch plus nicotine lozenges (Arch Gen Psychiatry, 66[11]:1253-1262).
   In the study, subjects had smoked at least 10 cigarettes daily for 6 months. All subjects were motivated to stop smoking. They were randomized to receive one of six treatments: nicotine lozenge, nicotine patch, sustained-release bupropion, nicotine patch plus nicotine lozenge, bupropion plus nicotine lozenge, or placebo. In addition, subjects had six individual counseling sessions.
   Subjects were assessed at 1 week, 8 weeks (when treatment ended), and 6 months after quitting. After analyzing the results, researchers found that although the nicotine lozenge, bupropion, and bupropion plus lozenge treatments produced effects comparable to those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit compared to placebo for smoking cessation.

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