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Pharmacologic classification: functionalized amino acid
Therapeutic classification: anticonvulsant
Pregnancy risk category: C
AVAILABLE FORMS
Tablets: 50 mg, 100 mg, 150 mg, 200 mg
Injection: 200 mg/20 ml vial
INDICATIONS AND DOSAGES
Adjunct therapy for partial-onset seizures—
Adults and adolescents age 17 and older: Initially, 50 mg P.O. b.i.d. Increase at weekly intervals to a maximum daily dose of 100 to 200 mg P.O. b.i.d. May administer I.V. over 30 to 60 minutes at an equivalent daily dose and frequency when P.O. administration is temporarily not feasible.
ADJUST-A-DOSE: In patients with mild or moderate hepatic impairment, maximum recommended daily dose is 300 mg. Withhold drug in patients with severe hepatic impairment.
CONTRAINDICATIONS AND CAUTIONS
Use cautiously in patients with known cardiac conduction problems, depression, myocardial ischemia, or heart failure and in those with a history of suicidal thoughts.
INTERACTIONS
None reported.
ADVERSE REACTIONS
CNS: asthenia, ataxia, balance disorder, depression, dizziness, fatigue, gait disturbance, headache, memory impairment, nystagmus, somnolence, tremor.
EENT: blurred vision, diplopia, vertigo.
GI: diarrhea, nausea, vomiting.
Skin: pruritus, skin laceration.
Other: contusion.
Reactions may be common, uncommon, life-threatening,
or COMMON AND LIFE-THREATENING.
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lacosamide