febuxostat
Uloric	Pharmaceutical company: Takeda Pharmaceuticals America www.uloric.com

Pharmacologic classification: xanthine oxidase inhibitor
Therapeutic classification: antigout drug
Pregnancy risk category: C

AVAILABLE FORMS
Tablets: 40 mg, 80 mg

INDICATIONS AND DOSAGES
Hyperuricemia associated with gout—
Adults: 40 mg P.O. daily. May increase dose to 80 mg after 2 weeks if uric acid levels remain above 6 mg/dl.

CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to the drug or its components and in those who are taking azathioprine, mercaptopurine, or theophylline.
   Use cautiously in patients with severe hepatic impairment (Child-Pugh Class C) or renal impairment (creatinine clearance less than 30 ml/minute).

INTERACTIONS
Drug-drug. Azathioprine, mercaptopurine, theophylline: May increase levels of these drugs, leading to toxicity. Use together is contraindicated.

ADVERSE REACTIONS
GI: nausea.
Musculoskeletal: arthralgia.
Skin: rash.

Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING.

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