doripenem
Doribax	Pharmaceutical company: Ortho-McNeil Pharmaceutical Co. www.ortho-mcneil.com

Pharmacologic classification: carbapenem
Therapeutic classification: antibiotic
Pregnancy risk category: B

AVAILABLE FORMS
Available forms: Single use vial 500 mg

INDICATIONS AND DOSAGES
Complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus, and Peptostreptococcus micros. Or complicated urinary tract infections, including pyelonephritis, caused by E. coli, K. pneumoniae, Proteus mirabilis, P. aeruginosa, and Acinetobacter baumannii--
Adults: 500 mg I.V. over 1 hour every 8 hours for 5 to 14 days for intra-abdominal infection; 500 mg I.V. over 1 hour every 8 hours for 10 days for UTI or pyelonephritis.
ADJUST-A-DOSE:
Patients with renal impairment--for those with creatinine clearance of 30 to 50ml/minute, give 250 mg I.V. every 8 hours; for those with creatinine clearance greater than 10 but less than 30 ml/minute give 250 mg I.V. every 12 hours.

CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to any component of the drug or drugs in this class, and in patients with history of anaphylactic reaction to beta-lactams.
   Use cautiously with sodium valproate therapy, and in pregnant or breast-feeding women.

INTERACTIONS
Drug-drug. Valproic acid: May significantly reduce serum levels of valproic acid and increase risk of seizures if combined. Avoid use together
Probenecid: May increase serum levels of doripenem. Avoid use together.

ADVERSE REACTIONS
CNS: headache.
CV: phlebitis.
GI: nausea, diarrhea.
Hematologic: anemia.
Hepatic: elevated liver enzymes.
Skin: pruritus, rash.
Other: infection, hypersensitivity reaction.

Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING.

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