dexrazoxane
Totect	Pharmaceutical company: Totect www.totect.com

Pharmacologic classification: lyophilizate
Therapeutic classification: tissue protectant
Pregnancy risk category: D

AVAILABLE FORMS
Single use vials: 500 mg

INDICATIONS AND DOSAGES
Extravasation resulting from I.V. anthracycline chemotherapy--
Adults: Give I.V. once daily for 3 days; day 1--1,000 mg/m2, maximum dose 2,000 mg; day 2--1,000 mg/m2, maximum dose 2,000 mg; day 3--500 mg/m2, maximum dose 1,000 mg. Infuse over 1 to 2 hours.
ADJUST-A-DOSE:
For patients with renal impairment with creatinine clearance less than 40 mL/minute, reduce dose by 50%.

CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to any component of the drug and in breast-feeding women.
   Use cautiously in patients with renal impairment, pregnancy. Safety hasn't been established in pediatric patients.

INTERACTIONS
None reported.

ADVERSE REACTIONS
CNS: depression, dizziness, fatigue, fever, headache, insomnia.
CV: edema, vascular disorders.
GI: anorexia, nausea, vomiting, diarrhea, stomatitis, abdominal pain, constipation.
Hematologic: anemia, bone marrow suppression.
Metabolic: elevated liver enzymes, increased creatinine level.
Respiratory: dyspnea, pneumonia, cough.
Skin: alopecia.
Other: infection, injection site pain and burning, injection site phlebitis, muscle pain.

Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING.

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