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|
 brimonidine tartrate and timolol maleate |
| Combigan |
Pharmaceutical
company:
Allergan, Inc.
www.allergan.com |
Pharmacologic classification: alpha adrenergic agonist/beta adrenergic inhibitor
Therapeutic classification: antiglaucomic, ophthalmic antihypertensive
Pregnancy risk category: C
AVAILABLE FORMS
Ophthalmic solution: brimonidine 0.2% and timolol 0.5%
INDICATIONS AND DOSAGES
To reduce elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension--
Adults: One drop in affected eye b.i.d., about 12 hours apart.
CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to any component of the drug, and in those with bronchial asthma, severe COPD, sinus bradycardia, heart block, overt heart failure, cardiogenic shock, and in breast-feeding women.
Use cautiously in patients with asthma, history of heart failure, mild to moderate COPD, vascular insufficiency, myasthenia gravis, multiple sclerosis, diabetes, hypoglycemia, myasthenic syndromes, and in pregnant women.
INTERACTIONS
Drug-drug.
Antihypertensives, cardioglycosides: Risk of further reduction in blood pressure. Use together cautiously.
Beta blockers: May increase beta-adrenergic blockade if combined with oral beta blockers. Avoid use together.
Calcium antagonists: May increase risk of conduction disturbances and heart failure. Avoid use together.
MAO inhibitors: May increase systemic side effects such as hypotension. Use together cautiously.
ADVERSE REACTIONS
CNS: headache, somnolence, depression, asthenia.
CV: chest pain, hypertension, arrhythmias, edema.
EENT: vision disturbance, conjunctivitis, blepharitis, corneal erosion, eye discharge, eye pain, eyelid edema, folliculosis, hyperemia, eye pruritus, ocular burning and stinging, tearing, foreign body sensation, oral dryness, superficial punctuate keratitis.
GI: oral dryness.
Respiratory: apnea, nasal congestion, bronchospasm.
Reactions may be common, uncommon, life-threatening,
or COMMON AND LIFE-THREATENING.
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