alvimopan
Entereg	Pharmaceutical company: GlaxoSmithKline www.entereg.com

Pharmacologic classification: peripherally-acting μ-opioid receptor antagonist
Therapeutic classification: opioid antagonist
Pregnancy risk category: B

AVAILABLE FORMS
Capsules: 12 mg

INDICATIONS AND DOSAGES
Accelerate recovery after partial large or small bowel resection surgery with primary anastomosis—
Adults: 12 mg P.O. 30 minutes to 5 hours before surgery; followed by 12 mg P.O. b.i.d. beginning the day after surgery, for a maximum of 15 doses. Drug is for hospital use only.

CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients taking opioids for more than 7 days immediately before taking this drug. Avoid use in patients with severe renal or hepatic impairment.
   Use cautiously in patients with a history of recent opioid use for chronic pain.

INTERACTIONS
None reported.

ADVERSE REACTIONS
GI: constipation, dyspepsia, flatulence.
GU: urinary retention.
Hematologic: anemia.
Metabolic: hypokalemia.
Musculoskeletal: back pain.

Reactions may be common, uncommon, life-threatening, or COMMON AND LIFE-THREATENING.

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