 aliskiren and hydrochlorothiazide |
| Tekturna HCT |
Pharmaceutical
company:
Novartis
www.novartis.com |
Pharmacologic classification: renin inhibitor, diuretic
Therapeutic classification: antihypertensive
Pregnancy risk category: D
AVAILABLE FORMS
Tablets: 150 mg aliskiren and 12.5 mg hydrochlorothiazide, 150 mg aliskiren and 25 mg hydrochlorothiazide, 300 mg aliskiren and 12.5 mg hydrochlorothiazide, 300 mg aliskiren and 25 mg hydrochlorothiazide.
INDICATIONS AND DOSAGES
Hypertension--
Adults: One tablet P.O. daily; adjust as needed to maximum dose of 300 mg/25 mg.
CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to any component of the drug or to sulfonamide-derived drugs.
Contraindicated in those with anuria or severe renal impairment and in pregnant or breast-feeding patients.
Use caution in the presence of hepatic impairment, systemic lupus erythematosus, dehydration, salt depletion.
INTERACTIONS
Drug-drug.
ACTH, corticosteroids: May increase electrolyte depletion. Monitor patient closely.
Antidiabetic drugs: May cause loss of glycemic control. Dosage adjustment of antidiabetic drug may be required. Monitor patient closely.
Antihypertensives: May have additive effect. Monitor patient closely.
Atorvastatin, ketoconazole: May significantly increase serum levels of aliskiren. Adjust dose as necessary and monitor patient closely.
Barbiturates, narcotics: May increase orthostatic hypotension. Use cautiously together.
Cholestyramine and colestipol resins: May impair absorption of hydrochlorothiazide. Separate doses by at least 2 hours.
Irbesartan: May reduce aliskiren levels. May need to adjust dosage of either drug and monitor patient closely.
Lithium: May increased risk of lithium toxicity. Avoid using together
NSAIDs: May cause loss of diuretic and antihypertensive effect if combined. Monitor patient closely.
Drug-lifestyle.
Alcohol use: May increase orthostatic hypotension. Advise patient to use cautiously together.
ADVERSE REACTIONS
CNS: asthenia, dizziness, vertigo.
CV: hypotension, orthostatic hypotension.
GI: nausea, diarrhea.
Respiratory: cough.
Other: angioedema, arthralgia, influenza.
Reactions may be common, uncommon, life-threatening,
or COMMON AND LIFE-THREATENING.
|
